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Then it was revealed that GlaxoSmithKline actually did have some trial data on its drug Paxil that it had never made public And the FDA had had that information all along Suddenly, the FDA was caught in the middle Companies submit reams of data to the agency, but by law the regulators must keep a lot of that secret For instance, the FDA gets all results from clinical trials that are conducted as part of a new drug or biologic application That information stays confidential unless the drug is approved, at which point only summaries are made public, under the theory that disclosing too many details could reveal trade secrets about how the drug was made As for trials that are conducted after a drug is in use typically, to get a supplemental application only the safety data must be reported promptly to the FDA.

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If by chance chromosomes 4 and 10 were selected and crossed over at point 2, the resulting children would be created

The effectiveness data can wait until the company actually decides to file for the supplemental application So, if the company never files, that information will never find is way to Rockville And if the FDA rejects the application, it is actually banned from making the data public In the case of off-label prescriptions like the pediatric use of antidepressants, people could keep taking pills even though the manufacturer knew quite.

A=1 Add-1 B=1 (3) [9] Add-2 Multiply-1 C=2 D=3 Add-3 (5) [5] Add-5 Double-1 Square-1

The value of the ice:editable attribute is initially set to an asterisk, which indicates that all editing options are available. If you turn off all the options, so that the content can only be changed but not styled, the ice:editing value is empty. Selecting one or more options will cause the available options to be written into the code, like this:

Document (Index: 0)

Measurement process piloting indicators Every process must have its own indicators. They are useful to assess the improvements achieved and the regressions. Some examples of indicators are: uncertainty of the measurement and test results; how many times nonconformity has been the result of a fault of the measurement process; rate of availability of the measurement process; operating costs of the measurement process.

If you are using either photoshop or Fireworks as your image editor, here is some good news: Dreamweaver works very closely with both photoshop and Fireworks, enabling you to create and modify images with round-trip ease. Find out more in 24.

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To preview your slide changes, you don t have to go outside of Dreamweaver. Just click and hold down the Play button on the Timelines panel.

One of a Web designer s greatest challenges is the ongoing maintenance of a site. In many situations, Web sites thrive on current information and, without continual updates, lose their effectiveness. Site maintenance is a prickly thorn bush for all involved: Web developers find it time-consuming and a distraction from their primary business, design. Web site owners want editorial control and immediate access without the technical administrative headaches. Adobe Contribute was introduced to solve the thorny problem of Web site upkeep. Contribute makes it easy for non-technical users to modify and add content to their Web sites; if your users are familiar with a word processor and a browser, they ll be able to master Contribute with little effort. After a content contributor has an established connection to a site a process Contribute greatly simplifies all he does is browse to a page, make his edits, and publish it back to the Web. The Contribute interface, shown in Figure 31-13, is designed with the non-technical user in mind.

Purpose Inherited Values Default Used In Specify a width for an outline No Same as border-width medium All elements

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Selection will usually amount to identifying candidate programs or methods that are t in principle for the intended purpose. A generalisation of a procedure developed by Underwood et al. (1993) for the selection of programs to test their capabilities to model plant and controls is illustrated in Fig. 7.13. Stage 1: Identify the application area and set criteria against which programs are to be evaluated Stage 2: Submit each program to an outline check-list of features that address adminstrative and non-technical aspects of the evaluation criteria such as requirements for user training, cost, hardware needs, etc. Stage 3: Filter candidate programs to a short-list based on general technical features and existing use Stage 4: Submit the short-listed programs to a detailed checklist of features that address technical and modelling capabilities of each program Stage 5: Program testing